What is the major difference between water-based inks and plastisol inks? And it is two things that concern people most in deciding on water-based or plastisol inks. The first thing is, plastisol inks never dry until they are heat cured at 330 degrees Fahrenheit for up to a minute or longer, depending on how much ink you print. The more plastisol ink you print, the more heat, and more time it will take to thoroughly cure the printed ink layer of top to bottom. With plastisol ink, the heat cur